EVALUATION OF PROLIFERATIVE ACTIVITY OF ENDOMETRIAL METAPLASIAS BY AGNOR TECHNOLOGY

EVALUATION OF PROLIFERATIVE ACTIVITY OF ENDOMETRIAL METAPLASIAS BY AGNOR TECHNOLOGY

Authors

  • TEONA TURASHVILI
  • GEORGE TEVDORASHVILI
  • GEORGE BURKADZE

Keywords:

proliferative activity, endometrial metaplasia, AgNOR

Abstract

           Endometrial metaplasia represents the transformation of glandular structures of the endometrium into other functionally and morphologically different tissue. The presence of endometrial metaplasia can be observed during other concomitant benign as well as malignant pathology. They can occur separately or with other histopathological changes. In the studied cases of endometrial metaplasia, the cases of immature squamous cell metaplasia are characterized by the maximum number of AgNOR staining and accordingly the maximum proliferative activity. In this group, the average number of AgNOR staining is 1.61 times higher than the mature squamous metaplasia and 2.44 times exceeds the average rate of ciliary metaplasia. Based on the above mentioned, additionally AgNOR staining is recommended to be used in routine diagnostic practice in cases of endometrial metaplasia as an additional method for evaluating proliferative activity.

Downloads

Download data is not yet available.

References

Kaku T, Tsukamoto N, Tsuruchi N, Sugihara K, Kamura T, Nakano H. Endometrial metaplasia associated with endometrial carcinoma. Obstetrics and Gynecology. 1992;80(5):812–6.

Johnson TL, Kini SR. Endometrial metaplasia as a source of atypical glandular cells in cervicovaginal smears. Diagn Cytopathol. 1996 Feb;14(1):25–31.

Hendrickson MR, Kempson RL. The differential diagnosis of endometrial adenocarcinoma. Some viewpoints concerning a common diagnostic problem. Pathology. 1980;12(1):35–61.

Nicolae A, Preda O, Nogales FF. Endometrial metaplasias and reactive changes: A spectrum of altered differentiation. J Clin Pathol. 2011 Feb;64(2):97–106.

Wu P, Lv Q, Guan J, Shan W, Chen X, Zhu Q, et al. Clinical implications of morular metaplasia in fertility-preserving treatment for atypical endometrial hyperplasia and early endometrial carcinoma patients. Arch Gynecol Obstet. 2022 Oct 1;306(4):1135–46.

Travaglino A, Inzani F, Santoro A, Arciuolo D, Piermattei A, Pasquini S, et al. Endometrial Metaplastic/Reactive Changes Coexistent with Endometrial Hyperplasia and Carcinoma: A Morphological and Immunohistochemical Study. Diagnostics (Basel) [Internet]. 2021 Dec 28 [cited 2023 Jul 7];12(1). Available from: http://www.ncbi.nlm.nih.gov/pubmed/35054228

Tamar Svanadze, Mariam Gachechiladze, George Burkadze. Problematic issues in the evaluation of molecular characteristics and potential neoplastic transformation of cervical metaplasia. EXPERIMENTAL AND CLINICAL MEDICINE GEORGIA, 2021; 4:51-58. https://doi.org/10.52340/jecm.2021.558

Metreveli B, Gagua D, Burkadze G, Kepuladze S. PROLIFERATIVE CHARACTERISTICS OF EUTOPIC AND ECTOPIC ENDOMETRIUM IN ADENOMYOSIS USING AgNOR TECHNOLOGY. GEORGIAN SCIENTISTS [Internet]. 2023 Jan 24 [cited 2023 May 14];5(1):59–71. Available from: https://journals.4science.ge/index.php/GS/article/view/1394

Tavdgiridze N, Tevdorashvili G, Kepuladze S, Burkadze G. ASSESSMENT OF PROLIFERATIVE ACTIVITY OF IMMATURE OVARIAN TERATOMAS USING AgNOR TECHNOLOGY. GEORGIAN SCIENTISTS [Internet]. 2023 Mar 21 [cited 2023 May 14];5(1):233–48. Available from: https://journals.4science.ge/index.php/GS/article/view/1567

Meshveliani P, Didava G, Tomadze G, Kepuladze S, Burkadze G. EVALUATION OF PROLIFERATIVE ACTIVITY OF PRE-TUMOR AND TUMOR PROCESSES OF BARRETT’S ESOPHAGUS USING AGNOR TECHNOLOGY. GEORGIAN SCIENTISTS [Internet]. 2023 Apr 23 [cited 2023 May 14];5(2):49–62. Available from: https://journals.4science.ge/index.php/GS/article/view/1687

Downloads

Published

2023-10-12

How to Cite

TURASHVILI, T., TEVDORASHVILI, G., & BURKADZE, G. (2023). EVALUATION OF PROLIFERATIVE ACTIVITY OF ENDOMETRIAL METAPLASIAS BY AGNOR TECHNOLOGY. EXPERIMENTAL AND CLINICAL MEDICINE GEORGIA, (5). Retrieved from https://journals.4science.ge/index.php/jecm/article/view/2170

Issue

Section

Articles

Similar Articles

1 2 3 4 5 6 7 > >> 

You may also start an advanced similarity search for this article.

Loading...