THE IMPACT OF GENETIC THROMBOPHILIA ON OBSTETRIC COMPLICATIONS AMONG GEORGIAN POPULATION
DOI:
https://doi.org/10.52340/jecm.2023.05.01Keywords:
genetic thrombophilia, obstetric complications, Georgian populationAbstract
During the research, 160 women were examined with the obstetrics complications. The following parameters were evaluated to determine genetic thrombophilia: Leiden and prothrombin mutation (heterozygous and homozygous); homozygous mutation of plasminogen activator inhibitor (PAI-1); deficiency protein C, protein S and antithrombin III. There were 82 (51.3%) patients (group I) who had thrombophilic disorders, 78 (48.7%), who made up group II, did not have any form of thrombophilic disorders. There was no statistically significant difference between women with a history of stillbirth and preeclampsia. Preterm birth was observed in 20 (24,4%) women in group I and in 7 (8,8%) women in group II. The difference is statistically significant, OR 3,27. The women with a history of thrombosis complications during pregnancy and postpartum period were 14 (17,1%) among group I, and 4 (5,1%) - group II. The difference is statistically significant, OR 3,8. According to our data, the women with a history of preterm birth and thrombosis complications during pregnancy and postpartum period should be screened for the diagnosis of genetic thrombophilia.
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Louise E. Simcox, Laura Ormesher, Clare Tower and Ian A. Greer. Thrombophilia and Pregnancy Complications. Int J Mol Sci. 2015 Dec; 16(12): 28418-28428.
Dautaj A, Krasi G, Bushati V, Precone V, Gheza M, Fioretti F, Sartori M, Costantini A, Benedetti S, Bertelli M. Hereditary thrombophilia. Published online 2019 Sep 30. doi: 10.23750/abm.v90i10-S.8758
Croles FN, Nasserinejad K, Duvekot JJ, Kruip MJ, Meijer K, Leebeek FW. Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and bayesian meta-analysis. 2017 Oct 26; 359: j4452. doi: 10.1136/bmj.j4452.
Rodger MA, Carrier M, le Gal G, Martinelli I, Perna A, Rey E, de Vries JI, Gris JC. Low-Molecular-Weight Heparin for Placenta-Mediated Pregnancy Complications Study Group. Meta-analysis of low-molecular-weight heparin to prevent recurrent placenta-mediated pregnancy complications. Blood 2014; 123(6):822-8.
Greer IA, Brenner B, Gris JC. Antithrombotic treatment for pregnancy complications: Which path for the journey to precision medicine? Br. J. Haematol. 2014; 165:585–599.
Rodger MA, Betancourt MT, Clark P, Lindqvist PG, Dizon-Townson D, Said J, Seligsohn U, Carrier M, Salomon O, Greer IA. The association of factor V Leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: A systematic review and meta-analysis of prospective cohort studies. PLoS Med. 2010, 7: e1000292.
Kramer MS, Kahn SR, Rozen R, Evans R, Platt RW, Chen MF, Goulet L, Se´Guin L, Dassa C, Lydon J, McNamara H, Dahhou M, Genest J. Vasculopathic and thrombophilic risk factors for spontaneous preterm birth. International Journal of Epidemiology 2009; 38:715-723. doi:10.1093/ije/dyp167
Naeye RL. Pregnancy hypertension, placental evidences of low uteroplacental blood flow, and spontaneous premature delivery. Hum Pathol. 1989; 20:441-44.
Salafia CM, Vogel CA, Vintzileos AM, Bantham KF, Pezzullo J, Silberman L. Placental pathological findings in preterm birth. Am J Obstet Gynecol. 1991; 165:934-38.
Arias F, Rodriquez L, Rayne SC, Kraus FT. Maternal placental vasculopathy and infection: two distinct subgroups among patients with preterm labor and preterm ruptured membranes. Am J Obstet Gynecol. 1993; 168: 585-91.
Chaiworapongsa T, Espinoza J, Yoshimatsu J et al. Activation of coagulation system in preterm labor and preterm premature rupture of membranes. J Matern Fetal Neonate Med. 2002; 2002:368-73.
Gibson CS, MacLennan AH, Janssen NG et al. Associations between fetal inherited thrombophilia and adverse pregnancy outcomes. Am J Obstet Gynecol 2006; 194: 947.e1-10.
Erhardt E, Stankovics J, Molnar D, Adamovich K, Melegh B. High prevalence of factor V Leiden mutation in mothers of premature neonates. Biol Neonate 2000; 78:145-46.
Gopel W, Kim D, Gortner L. Prothrombotic mutations as a risk factor for preterm birth. Lancet 1999; 353:1411-12.
Werner EF, Lockwood CJ. Thrombophilias and Stillbirth. Clin Obstet Gynecol. Sep 2010; 53(3):617-627. doi: 10.1097/GRF.0b013e3181eb658c.
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