PEMPHIGUS VULGARIS, CURRENT STATUS AND PROSPECTS

PEMPHIGUS VULGARIS, CURRENT STATUS AND PROSPECTS

Authors

  • NATO KORSANTIA
  • ALEXANDER KATSITADZE
  • NINO KORSANTIA
  • LELA BERIDZE
  • TEA KATSITADZE

DOI:

https://doi.org/10.52340/jecm.2023.03.14

Keywords:

Pemphigus vulgaris, treatment, side effects

Abstract

Pemphigus vulgaris refers to a group of autoimmune blistering diseases of skin and mucous membranes. Like other autoimmune diseases, what causes the pemphigus diseases is not really understood. Researchers believe genetic and environmental factors may influence the disease. The article presents various methods of treatment of pemphigus vulgaris, with its pros and cons. It is important that each method and dosage are properly chosen to achieve a positive therapeutic effect on the background of minimal side effects.

Downloads

Download data is not yet available.

References

Kaegi C, Wuest B, Schreiner J, et al. Systematic review of safety and efficacy of rituximab in treating immune-mediated disorders. Front Immunol. 2019;10:1990. doi:10.3389/fimmu.2019.01990

Cheesman S. Introduction of biosimilar rituximab: a hospital perspective. Hemasphere. 2020;5(1):e515.

Brochado MJF, Nascimento DF, Campos W, Deghaide NHS, Donadi EA, Roselino AM. Differential HLA class I and class II associations in pemphigus foliaceus and pemphigus vulgaris patients from a prevalent Southeastern Brazilian region. J Autoimmun. 2016;72:19–24. doi:10.1016/j. jaut.2016.04.007

Walsh P, Brochado MJF, Vernal S, et al. Relationship between pemphigus and American tegumentary leishmaniasis: insights from serological and genetic profiles. Trans R Soc Trop Med Hyg. 2017;111(8):345–53.

Salathiel AM, Brochado MJF, Kim O, Deghaide NHS, Donadi EA, Roselino AM. Family study of monozygotic twins affected by pemphigus vulgaris. Hum Immunol. 2016;77(7):600–604.

Fania L, Moro F, De Paolis E, et al. Pemphigus vulgaris in two pairs of siblings from two unrelated Italian families: human leukocyte antigen genotypes, ST18 mutation and immunological profile. J Dermatol. 2021;48(2):211–214. doi:10.1111/1346-8138.15656

Malik AM, Tupchong S, Huang S, Are A, Hsu S, Motaparthi K. An updated review of pemphigus diseases. Medicina. 2021;57(10):1080. doi:10.3390/medicina57101080

Kridin K. Pemphigus group: overview, epidemiology, mortality, and comorbidities. Immunol Res. 2018;66(2):255–270. doi:10.1007/s12026-018-8986-7

Didona D, Maglie R, Eming R, Hertl M. Pemphigus: current and Future Therapeutic Strategies. Front Immunol. 2019;10:1418. doi:10.3389/ fimmu.2019.01418

Yuan H, Pan M, Chen H, Mao X. Immunotherapy for Pemphigus: Present and Future. Front Med (Lausanne). 2022 Jun 15; 9:901239. Doi: 10.3389/fmed.2022.901239

Schmidt E, Zillikens D. Modern diagnosis of autoimmune blistering skin diseases. Autoimmun Rev. 2010;10(2):84–89. PMID: 20713186.

Pohla Gubo G, Hintner H. Direct and indirect immunofluorescence for the diagnosis of bullous autoimmune diseases. Dermatol Clin. 2011;29(3):365–372, vii. PMID: 21605801.

Venugopal SS, Murrell DF. Diagnosis and clinical features of pemphigus vulgaris. Dermatol Clin. 2011;29(3):373–380. PMID: 21605802

Aimee S. Payne, John R. Stanley. Pemphigus. Fitzpatrick’s Dermatology in general medicine. Section 8. Chapter 54. P 586-599.

Tran KD, Wolverton JE, Soter NA. Methotrexate in the treatment of pemphigus vulgaris: experience in 23 patients. Br J Dermatol. 2013 Oct;169(4):916-21. doi: 10.1111/bjd.12474. PMID: 23772610.

Baum S, Greenberger S, Samuelov L, Solomon M, Lyakhovitsky A, Trau H, Barzilai A. Methotrexate is an effective and safe adjuvant therapy for pemphigus vulgaris. Eur J Dermatol. 2012 Jan-Feb;22(1):83-7. doi: 10.1684/ejd.2011.1611. PMID: 22266247.

Barthelemy H, Frappaz A, Cambazard F, Mauduit G, Rouchouse B, Kanitakis J, Souteyrand P, Claudy AL, Thivolet J. Treatment of nine cases of pemphigus vulgaris with cyclosporine. J Am Acad Dermatol. 1988 Jun;18(6):1262-6. doi: 10.1016/s0190-9622(88)70132-2. PMID: 3385040.

Schiavo AL, Puca RV, Ruocco V, Ruocco E. Adjuvant drugs in autoimmune bullous diseases, efficacy versus safety: facts and controversies. Clin Dermatol. 2010;28(3):337–343.

Downloads

Published

2023-09-18

How to Cite

KORSANTIA, N., KATSITADZE, A., KORSANTIA, N., BERIDZE, L., & KATSITADZE, T. (2023). PEMPHIGUS VULGARIS, CURRENT STATUS AND PROSPECTS. Experimental and Clinical Medicine Georgia, (3). https://doi.org/10.52340/jecm.2023.03.14

Issue

Section

Articles

Most read articles by the same author(s)

1 2 > >> 
Loading...