ALKALOIDS OF ABOVEGROUND ORGANS OF DELPHINIUM FREYNII CONRATH COMMON IN GEORGIA AND THEIR ANALGESIC ACTIVITY
DOI:
https://doi.org/10.52340/jecm.2023.02.04Keywords:
Alkaloid, Delphinium freynii, Helleboraceae, methyllicaconitine, analgesic activityAbstract
The aim of the research was to study the aerial organs of Delphinium freynii conrath, common in Georgia, for the content of alkaloids and to determine their pharmacological activity. It was found that the sums of bases obtained by two methods are identical in terms of the qualitative composition of alkaloids and contain diterpene bases: methyllicaconitine, delfrenine, songoramine, anthranoillicoctonine, norzongoramine, norzongoine, delflexine, lycoctonine. In sum I (classical method), pharmacologically active methyllycaconitine dominates, and in sum II (extraction with 2% H2SO4) lyoctonine dominates. In “Hot plate” assay both samples reveal doze-dependent analgesic activity, reaching a maximum one hour after administration.
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References
Bessone F. Non-steroidal anti-inflammatory drugs: What is the actual risk of liver damage? World J Gastroenterol. 2010, 16(45): 5651–5661. doi:10.3748/wjg.v16.i45.5651.
Kumar D. et al. Free Radical Scavenging and Analgesic Activities of Cucumis sativus L. Fruit Extract. J Young Pharm. 2010, 2(4):365-8. doi: 10.4103/0975-1483.71627.
Ling Zhuang, Tao Li et al. Diterpenoid alkaloids from Delphinium ajacis and Their Anti-RSV Activities. Planta Medica, 2017, 83: 1-184.
Liu, F.; Yang, C.H.; Liang, J.Y.; Liu, J.H. Advances in the studies on the pharmacological activities and toxicities of C19 diterpenoid alkaloids. Strait Pharm. J. 2012,24: 1–5.
Shan, L., Zhang, J. et al. Diterpenoid Alkaloids from Delphinium anthriscifolium var. majus. Sci Rep. 2017, 7: 6063.
Wang, J.L.; Shen, X.L.; Chen, Q.H.; Wang, W.; Wang, F.P. Structure-analgesic Activity Relationship Studies on the C18-and C19-Diterpenoid Alkaloids. Chem. Pharm. Bull. 2009, 57: 801–807.
Faridi, B.; Zello, A.; Touati, D.; Alaoui, K.; Cherrah, Y. Toxicite aigue et activite anti-inflammatoire des grains de Delphinium staphysagria. Phytotherapie 2014, 12: 175–180.
Xu, T.F.; Liu, S.; Meng, L.L.; Pi, Z.F.; Liu, Z.Q. Bioactive heterocyclic alkaloids with diterpene structure isolated from traditional Chinese medicines. J. Chromatogr. B 2016,1026: 56–66.
Кобелянская Л. Г. Применение метилликаконитина в клинике нервных болезней при спастических парезах. Фармакология и Токсикология. 1959, 1: 38-42.
Коваленков К.М. Фармакологическая характеристика отечественны заменителей кураре, их действие на нервно-мышечный аппарат. Фармакология и Токсикология. 1952, 1: 43-51
Gagnidze, R. Vascular plants of Georgia a nomenclatural checklist. Tbilisi.: “Universal” 2005: 33-34.
L. Kintsurashvili, K. Mulkijanyan, N. Gogitidze, N. Mushkiashvili. Alkaloids from the Aerial Parts of Larkspur (Delphinium speciosum Beeb.) and their Pharmacological Activity. Ijppr.Human.2020,18 (4):204-11
Directive 2010/63 / EU of the European Parliament and of the Council of the European Union of 22 September 2010 on the protection of animals used for scientific purposes. Official J of the European Union L.2010,276,53: 33-80.
Guide for the care and use of laboratory animals. 8th ed. The National Academies Press. 2011.
Milind P, Monu Y. Laboratory models for screening analgesics. International Research Journal of Pharmacy. 2013, 4(1): 15-19.
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