АNXIETY AND DEPRESSION IN PREDICTING THE RISK OF CHRONIC SPONTANEOUS URTICARIA (CSU) AND ATOPIC DERMATITIS (AD)
DOI:
https://doi.org/10.52340/jecm.2022.07.19Keywords:
anxiety, depression, chronic spontaneous urticaria, atopic dermatitisAbstract
Previous research has shown that anxiety and depression are associated with many chronic skin diseases, including chronic spontaneous urticaria (CSU) and atopic dermatitis (AD). A causal relationship between these phenomena has not yet been established. Most authors believe that these itchy conditions cause anxiety, depression, and insomnia rather than the other way around. In our work, we attempted to assess the predictive value of anxiety and depression as risk factors for chronic urticaria and atopic dermatitis. We aimed to investigate the impact of depression and anxiety as risk factors for atopic dermatitis and urticaria. We also assessed the predictive value of the logistic regression method in prospective observational clinical trials. The study included 120 patients suffering from chronic spontaneous urticaria and 110 patients with atopic dermatitis registered at the university clinics of TSMU for 2018-2021 years. A comparison of risk concentration in the studied groups was carried out according to the Lorenz curve and by calculating the Gini coefficient. It is concluded that depression and anxiety are considered significant risk factors for developing chronic spontaneous urticaria and, to a lesser extent, atopic dermatitis. The Lorenz curve characterizes the concentration of the risk of morbidity in individuals with the most significant threat. It can be successfully used to predict the development of chronic spontaneous urticaria.
Downloads
References
Altinцz AE, Taşkintuna N, Altinцz ST, Ceran S (2014) A cohort study of the relationship between anger and chronic spontaneous urticaria. Adv Ther 31:1000–1007;
Chu CY, Cho YT, Jiang JH, Chang CC, Liao SC, Tang CH (2019) Chronic urticaria patients have a higher risk of psychiatric disorders: a population-based study. Br J Dermatol. https ://doi. org/10.1111/bjd.18240;
Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelley KW (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9:46–56;
Green C, Yu BN, Marrie RA. Exploring the implications of smallarea variation in the incidence of multiple sclerosis. Am J Epidemiol. 2013; 178:1059–1066;
Huang Y, Pepe MS. Assessing risk prediction models in case-control studies using semiparametric and nonparametric methods. Stat Med. 2010; 29:1391–1410;
Janes H, Pepe M, Kooperberg C, Newcomb P. Identifying target populations for screening or not screening using logic regression. Stat Med. 2005;24:1321–1338;
Katon WJ (2011) Epidemiology and treatment of depression in patients with chronic medical illness. Dialogues Clin Neurosci 13:7–23;
Konstantinou GN, Konstantinou GN (2019) Psychiatric comorbidity in chronic urticarial patients: a systematic review and metaanalysis. Clin Transl Allergy 9:42;
lorca L J, Delgado-Rodrнguez M. Visualising exposure-disease association: the Lorenz curve and the Gini index. Med Sci Monit. 2002;8: MT193–MT197;
Lorenz MO. Methods of measuring the concentration of wealth. J Am Stat Assoc. 1905; 9: 209–219;
Miller AH, Raison CL (2016) The role of inflammation in depression:from evolutionary imperative to modern treatment target. Nat Rev Immuno 16:22–34;
Pepe MS, Feng Z, Huang Y, et al. Integrating the predictiveness of a marker with its performance as a classifier. Am J Epidemiol. 2008; 167:362–368;
Ponarovsky B, Amital D, Lazarov A, Kotler M, Amital H (2011) Anxiety and depression in patients with allergic and non-allergic cutaneous disorders. Int J Dermatol 50:1217–1222;
Remrod C, Sjostrom K, Svensson A (2015) Pruritus in psoriasis: a study of personality traits, depression and anxiety. Acta Derm Venereol 95:439–443;
Steyerberg EW, Moons KG, van der Windt DA, et al.; PROGRESS Group. Prognosis Research Strategy (PROGRESS) 3: prognostic model research. PLoS Med. 2013;10:e1001381;
Tat TS (2019) Higher levels of depression and anxiety in patients with chronic urticaria. Med Si Monit 25:115–120;
Telia, Z. (2022). Anxiety and depression in patients with chronic urticaria. Georgian Scientists, 4(4), 253-260. https://doi.org/10.52340/gs.2022.04.04.28
Telia, Z., Machavariani, K., & Telia, A. (2022). The association of atopic dermatitis (AD) with anxiety and depression. Georgian Scientists, 4(4), 261-267. https://doi.org/10.52340/gs.2022.04.04.29
Tey HL, Wallengren J, Yosipovitch G (2013) Psychosomatic factors in pruritus. Clin Dermatol 31:31–40.
Downloads
Published
How to Cite
Issue
Section
