nitrofurans, metabolites, food


Nitrofurans (furazolidone, furaltadone, nitrofurantoin, nitrofurazone) belong to a wide range of synthetic antibiotics used in the prevention of gastrointestinal infections in livestock, aquaculture and beekeeping. They were also used as food supplements to stimulate growth. In 1995, the use of nitrofurans in veterinary medicine was banned in the European Union because of the carcinogenic and potentially harmful effects in humans. Illegal use of nitrofurans in the EU is controlled by official inspection and analysis services. In accordance with the requirements of Council of Europe Directive 96/23/EC, the content of nitrofurans in live animals and food of animal origin is also controlled by the Government of Georgia. Screening, immunoenzymatic method of analysis is currently used to monitor nitrofurans and their wastes. In accordance with the new, strict regulations and validation requirements of analytical methods set by the Council of Europe, it is necessary to develop highly sensitive and specific analysis methods for the determination of nitrofuran residues in food. Calculate extraction coefficients for waste determination in different matrices using the developed method and validate the developed method.


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