LATE SENESCENCE AND AGING OF OLIGODENDROCYTES

ანოტაცია

The total number of oligodendrocytes  decreases  during the period of late senescence as in the unit area of  pyramidal layer of the cortex, as well as the surrounding white matter.  Besides, decrease in the number of oligodendrocytes is being performed at the expence of the decrease of newly created oligodendrocytes, defferenciating cells and the number of already differentiated adult cells realizing the specific functions. The physiological death of neurocytes during  the  late senescence is accompanied by  the physiologicsl death and loss of  anatomically and functionally related oligodendrocytes,  resulted in an increase of  share of  the apoptotic  cells in the  total  number  of  oligodendrocytes. The fact that all types of cells including apoptocic cells  in the old organisms are  smaller in size –is  expression of gerogenic changes. During  apoptosis of smaller  cells, aging  cells undergo  fragmentation into  smaller parts in comparison of  the relatively large size cells of young organisms. Thus, apoptosis in aging body has its gerogenic characteristics.