CLOSTRIDIUM DIFFICILE INFECTION: CLINICAL FEATURES AND RISK FACTORS OF DEVELOPING DIARRHEA
Clostridium difficile infection is a leading cause of hospital-associated gastrointestinal illness and places a high burden on health-care system. The aim of the study was to investigate clinical features and risk factors of C.difficile infection among hospital admissions at the somatic departments of Tbilisi University clinics. C.difficile infection was confirmed by clinical features and positive ELISA stool test for Toxins A and B., and nucleic acid amplification tests for C, difficile toxin genes such as PCR a toxins A and B and glutamate dehydrogenase screening, The study included 71 patients between the ages of 1880. Male -55% Female 45% C, difficile infection was confirmed in 12 cases [17%]. Clinical presentation of Clostridium difficile infection range from mild to severe watery diarrhea, abdominal distension and fiver. Old age, underlying illnesses ,3 generation cephalosporin or carbapenem exposure in preceding 30 days before diagnosis, prolonged hospital stay, administration of proton pump inhibitors in critically ill patients are associated with increased risk of developing Clostridium difficile diarrhea.
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