How to Cite

წერეთელი მ. T. M., & ვაშაკიძე ე. V. E. (2021). CLOSTRIDIUM DIFFICILE INFECTION: CLINICAL FEATURES AND RISK FACTORS OF DEVELOPING DIARRHEA. Collection of Scientific Works of Tbilisi State Medical University, 50, 128–130. Retrieved from


Clostridium difficile infection  is a leading cause of hospital-associated gastrointestinal illness and places a high burden on health-care system. The aim of the study was to  investigate clinical features and  risk factors of C.difficile infection among  hospital admissions  at the somatic departments of Tbilisi University clinics. C.difficile infection was confirmed by clinical features and  positive ELISA stool test for Toxins A and B., and nucleic acid amplification tests for C, difficile toxin genes such as  PCR a toxins A and B and  glutamate dehydrogenase screening, The study included 71 patients between the ages of 1880.  Male  -55%  Female 45% C, difficile infection was confirmed in 12 cases [17%]. Clinical presentation of Clostridium difficile infection range from mild to severe watery diarrhea, abdominal distension and fiver. Old age, underlying illnesses ,3  generation cephalosporin or carbapenem exposure in preceding 30 days before diagnosis, prolonged hospital stay, administration  of proton pump inhibitors in critically ill patients are associated with increased risk of developing Clostridium difficile diarrhea.



Surawicz CM, Brandt LJ, Binion DG, et al. Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections. Am J Gastroenterol 2013;108(4):478-98.

Ghose C. Clostridium difficile infection in the twentyfirst century. Emerg Microbes Infect. 2013 Sep;2(9):e62. doi: 10.1038/emi.2013.62. Review.

Brian K. Yorkgitis, PA-C, DO, Victoria Frain, MSN, RN, CRNP. Clostridium difficile InfectionClinician Reviews. 2011 December;21(12):41-46

Luis Furuya-Kanamori, John Marquess, Laith Yakob, Thomas V. Riley, David L. Paterson, Niki F. Foster, Charlotte A. Huber, and Archie C. A. Clements. Asymptomatic Clostridium difficile colonization: epidemiology and clinical implications. BMC Infect Dis. 2015; 15: 516. Published online 2015 Nov 14. doi: 10.1186/s12879-0151258-4.

Poutanen SM, Simor AE: Clostridium difficile–associated diarrhea in adults. CMAJ 2004; 171:51-58.

Cohen SH, Gerding DN, Johnson S, et al. Clinical Practice Guidelines for Clostridium difficile Infection in Adults: 2010 Update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA) . MD Source: Infection Control and Hospital Epidemiology, Vol. 31, No. 5, May 2010;431-455 Published by: The University of Chicago Press on behalf of The Society for Healthcare Epidemiology of America.

Bauer M., Van Dissel J. Alternative strategies for Clostridium difficile infection // J. Antimicrob. Agents. 2009. Vol. 33 (1). P. 51–56

Cohen S., Peroling D., Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA) // Infect. Control. Hosp. Epidemiol. 2010. Vol. 31 (5). P. 431–455.

Lessa FC, Mu Y, Bamberg WM, Beldavs ZG, Dumyati GK, et al. Burden of Clostridium difficile Infection in the United States. N Engl J Med 2015; 372:825-34.

Centers for Disease Control and Prevention (CDC). Antibiotic resistance threats in the United States, 2013. Atlanta: CDC; 2013. Available from: drugresistance/threat-report-2013/pdf/ar-threats-2013508.pdf

CDC. Multidrug-resistant organism & Clostridium difficile Infection. (MDRO/CDI) module 2016; 2; 1-42. 12. McDonald LC, Coignard B, Dubberke E, et al. Recommendations for Surveillance of Clostridium difficile–Associated Disease. J. Infect Control Hospital Epidemiol 2007; 28: 2; 140-5.

Sunenshine & McDonald Cleve Clin J Med 2006; 73(2):187-197

Hensgens et al. J Antimicrob Chemother 2012; 67(3):742-748 15. Buendgens L, Bruensing J, Matthes M. et al. J Crit Care 2014; 29 (4), 696.e11-696.e

Administration of proton pump inhibitors in critically ill medical patients is associated with increased risk of developing Clostridium difficile-associated diarrhea.

Chih-Huan C, Chi-Jung W, Hsin-Chun L, et al. Clostridium difficile infection at a medical center in Southern Taiwan: incidence, clinical features and prognosis. Journal of Microbiol. Immunol. Infect. 2010; 43 (2): 119–125.


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