THE ROLE OF GUT MICROBIOTA IN PATIENTS WITH DIABETES TYPE 2 AND INSULIN RESISTANCE

Authors

DOI:

https://doi.org/10.52340/csw.2021.435

Keywords:

Diabetes mellitus, insulinresistance, gut microbiota

Abstract

Diabetes mellitus is one of the most common chronic disease. In a number of developing and industrialized countries, diabetes mellitus has become an epidemic and is one of the leading causes of death.  The rapid increase of cases of type 2 diabetes mellitus (T2DM) in the past decades has made it a widespread metabolic disorder. In recent years, an increasing understanding of how our microflora is linked to obesity-related T2DM has provided a new potential target for reducing the risk of T2DM. The aim of our project is to expand our view on the key roles of microflora during the onset and development of T2DM as well as its complications. Our aim was to study 2 groups of people with T2DM and Prediabetes in order to reveal any gastro-intestinal problems. According to questionnaires, it appeared that patients with diabetes type 2 had 3 or more gastrointestinal disorders, 72 % had bloating, 16% constipation and 12% diarrhea. Patients with prediabetes had 3 and more intestinal disorders: 56 % had bloating, 23% constipation and 21 % diarrhea. Despite, multiple studies supporting the importance of gut microbiota in pathophysiology of T2DM, the field is in early stage. Currently, we have reached a point in our understanding that some probiotics and related molecular mechanisms may be involved in glucose metabolism related to T2DM. We should work towards precision/personalized medicine selecting anti-diabetics and probiotics for a given patient to treat patients successfully.

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Author Biographies

Katamadze Natia, Tbilisi State Medical University

TSMU, DEPARTMENT OF INTERNAL MEDICINE

Kandashvili Tamar, Tbilisi State University

Doctor of Medical Sciences

TSMU, N 3 DEPARTMENT OF INTERNAL MEDICINE

 

Metreveli David, Tbilisi State University

TSMU, DEPARTMENT OF INTERNAL MEDICINE

Gordeladze David, Tbilisi State University

TSMU, DEPARTMENT OF INTERNAL MEDICINE

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Published

2021-07-23

How to Cite

Katamadze Natia, Kandashvili Tamar, Metreveli David, & Gordeladze David. (2021). THE ROLE OF GUT MICROBIOTA IN PATIENTS WITH DIABETES TYPE 2 AND INSULIN RESISTANCE. TSMU COLLECTION OF SCIENTIFIC WORKS, 54. https://doi.org/10.52340/csw.2021.435

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