HEMOLYTIC-UREMIC SYNDROME AND AMEBIC DYSENTERY IN GEORGIA: (Case report)

Abstract

The number of patients with HUS syndrome was significantly increased in 2009-2011. Comprehensive investigations of etiological structure of hemorrhagic colitis and cases complicated by HUS (bacteriological, immunoferment-ImmunoCard STAT and PCR methods) was performed. The research is conducted in the Centers of Infectious Diseases and National Center for Disease Control and Prevention (NCDC). 25 cases of amebic dysentery were revealed in the research process in summer 2012. The course of the diseases was complicated by HUS in 2 cases. Both patients were female, 65 and 36 years. One of them was at 14 weeks of pregnancy. The pregnant patient required dyalisis and the other - 65 old year female was under the observation of nephrologists. There was no lethality. Amebic dysentery in above represented cases was confirmed by stool antigen test (EIA, sensitivity -100%‚ specifity-94‚7%), but by bacteriological analyzes of stool specimens no enteropathogenic bacteria was isolated, and no shiga-toxin (stxl, stx2) was identified by PCR method. It should be noted that our observation is important in its significance as our patients with HUS received purposeful investigations to reveal enterohemorrhagic E.coli. According to the literature data an association between Amebic dysentery and HUS has been mentioned, but a cause and effected relationship has never been confirmed.