SARS-CoV-2 pandemic has had a significant impact on the entire society and especially on its vulnerable group, such as drug users. The aim of the study was to determine the behavioral patterns of users of state methadone replacement therapy (MRT) programs during the pandemic. The study was conducted in four focus groups. As a result of the research, it was determined: SARS-CoV-2 the pandemic had a significant impact on the patients. As a positive factor, the fact that the relationship with medical institutions and the information received from them significantly increased the awareness of patients in terms of the prevention of Covid-19. At the same time, patients noted an increase in anxiety related to their and their loved ones being infected with Covid-19. The measures implemented by the state to prevent the spread of Covid-19 in the programs of MRT (taking home a 5-day dose of replacement medicine) caused a double result: Most patients find that it improves their mood and sense of comfort. At the same time, there was an increase in the misuse of drugs taken at home (injection use, taking a 5-day dose in 3-4 days and then using other drugs/psychotropic substances), and in rare cases, there was an alienation/exchange of belonging methadone for street drugs. These findings are important for the future planning and implementation of opioid substitution therapy (OST) programs.
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