• Gvilava I. გვილავა ი.
  • Ormotsadze G. ორმოცაძე გ.
  • Kiparoidze S. კიპაროიძე ს.
  • Giorgobiani M. გიორგობიანი მ.
  • Sanikidze T. სანიკიძე თ.



The purpose of the study was an investigation of the radioprotective activity of citrus polimetoxilated flavonoids extract in an animal model system. The intensification of oxidative stress and lipid peroxidation in the X- rays irradiated rats was detected, that was revealed by intensive LOO - production and inactivation of antioxidant enzymes (catalase and SOD) in the animal’s blood. Intensification of lipoperoxidation shows periodic character (after 1 and 4 days), that is due to X- rays initiated intensification of secondary oxygen and lipids free radical production after some days after irradiation. 7-day treatment of irradiated rats with the extract of citrus polimetoxilated flavonoids induced decrease of intensivity of lipoperoxides production and normalization of activity of antioxidant enzymes. Based on the analysis of the investigation results we suggested that the citrus polimetoxilated extract revealed antioxidant activity.


Download data is not yet available.


Metrics Loading ...


1. Dörr W. Radiation effect in normal tissue - principles of damage and protection. Nuklearmedizin. 2010;49, 1:S53-8.
2. Mettler FA Jr, Brenner D, Coleman CN, Kaminski JM, Kennedy AR, Wagner LK.. Can radiation risks to patients be reduced without reducing radiation exposure? The status of chemical radioprotectants. AJR Am J Roentgenol. 2011, 196(3):616-8.
3. Schwartz DL, Hutcheson K, Barringer D, Tucker SL, Kies M, Holsinger FC, Ang KK, Morrison WH, Rosenthal DI, Garden AS, Dong L, Lewin JS. Candidate dosimetric predictors of long-term swallowing dysfunction after oropharyngeal intensity-modulated radiotherapyInt J Radiat Oncol Biol Phys. 2010, 1;78(5):1356-65.
4. Tabatabaie T, Kotake Y, Wallis G, Jacob JM, Floyd RA. Spin trapping agent phenyl N-tert-butylnitrone protects against the onset of drug-induced insulin-dependent diabetes mellitus. FEBS Lett. 1997 Apr 28;407(2):148-52




How to Cite

გვილავა ი. G. I., ორმოცაძე გ. O. G., კიპაროიძე ს. K. S., გიორგობიანი მ. G. M., & სანიკიძე თ. S. T. (2019). ANTIOXIDANT ACTIVITY OF CITRUS POLIMETOXILATED FLAVONOIDS EXTRACT. TSMU COLLECTION OF SCIENTIFIC WORKS, 49, 26–28.

Most read articles by the same author(s)