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Tsiskarishvili, T., Katsitadze, A., Tsiskarishvili, N., & Korsantia, N. (2019). THE MODERN CONCEPTS OF THE ETIOLOGY AND PATHOGENESIS OF ROSACEA. Collection of Scientific Works of Tbilisi State Medical University, 51, 121–124.


       Rosacea is a chronic, widespread dermatosis with a predominance of skin lesions. Clinically is manifested by the centrofacial erythema, edema, telangiectasias, papular and pustular rashes, by the development of foci of hyperplasia of the sebaceous glands and the progressive proliferation of connective tissue. The article presents the modern aspects of the etiology and pathogenesis of rosacea. In particular, the authors consider the main hypotheses of pathogenesis: vascular disorders, degeneration of the dermal matrix, environmental factors and microorganisms (Demodex folliculorum- Helicobacter pylori), the participation of adaptive and innate immunity (the role of antimicrobial peptides-cathelicidin) of pro-inflammatory cytokines (vascular endothelial factor). An important link in the pathogenesis of rosacea is hormonal dysfunctions, especially sex hormones. The literature review is ended with the conclusion that the complexity and multivectorness of the pathogenesis of rosacea creates the need for a comprehensive approach when examining patients, with the involvement of specialists in related specialties.


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