Abstract
Rosacea is a chronic, widespread dermatosis with a predominance of skin lesions. Clinically is manifested by the centrofacial erythema, edema, telangiectasias, papular and pustular rashes, by the development of foci of hyperplasia of the sebaceous glands and the progressive proliferation of connective tissue. The article presents the modern aspects of the etiology and pathogenesis of rosacea. In particular, the authors consider the main hypotheses of pathogenesis: vascular disorders, degeneration of the dermal matrix, environmental factors and microorganisms (Demodex folliculorum- Helicobacter pylori), the participation of adaptive and innate immunity (the role of antimicrobial peptides-cathelicidin) of pro-inflammatory cytokines (vascular endothelial factor). An important link in the pathogenesis of rosacea is hormonal dysfunctions, especially sex hormones. The literature review is ended with the conclusion that the complexity and multivectorness of the pathogenesis of rosacea creates the need for a comprehensive approach when examining patients, with the involvement of specialists in related specialties.
References
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9. Хебиф Т.П Кожные болезни: диагностика и лечение Пер. с анг. под ред. акад. А. А Кубановой.
10. Abram K,Silm H., Maaroos HL., Oona M. Rsk factors associated with rosacea . J Eur Acad Dermatol Venereol 2010; 24: 565 -71
11. Aroni K.,Tsagroni E., Kavantas N. et al A study of the pathogenesis of rosacea . : how agiogenesis and mast cells may participate in a complex multifactorial process. Arch Dermatol Res 2008: 300: 125 -131
12. Wilkin JK. A role for vascular pathogenic mechanisms im rosacea : implications for patient care. Cutis 2008: 82 (2): 100-2
13. Webster GF. Rosacea. Med Clin North Am .2009 Nov (6) : 1183 -94
14. Shuber J,Gallo RL Antimicrobal peptides and the skin immune defense system. J Allergy Clin Immunol 2009: 124 (Suppl 2): 13-18
15. Smith JR, Lamier VB, Braziel RM. et al. Expression of vascular endothelial growth factor and its receptor in rosacea. Br J Oftalmol 2007: 91: 226 9
16. Slichcic A. The link between Helicobacter pylory infection and rosacea J Eur Acad Dermatol Venereol 2002 : 16: 328 -33
17. Shwab V. D.., Sulk M., Seeliger S et al. Neurovascular and neuroimmune aspects in the pathophysiology of rosacea J Invest Dermatol symp Proc 2011: 1: 53-62
18. Yamasaki K, Di Nardo A, Bardan A et al. Increased serine protease activity and catelicidin promotes skin inflammation in rosacea. Nat Med 2007; 13; 975 -80
19. Yamasaki K., Gallo RL., The molecular pathology of rosacea J Dermatol Sc. 2009 Aug; 55(2); 77-81
20. Jones DA., Rosacea, reactive oxygen species and azelaic acid. J Clin Aesthet Dermatol 2009 ; 2(1); 26 -30
21. Kyriakis K., Palamaras I, Terzoidi S et al. Epidemiologie aspects of rosacea. J Am Acad Dermatol 2005;53; 918 -9
22. Kligman A.M. A personal critigue on the state of rnowledge of Rosacea Dermatology Dermatology 2008;191 -198
23. Laguer V., Hoang V,Nguyen A et al. Angiogenesis in cutaneous disease; part II . J Am Acad Dermatol 2009; 61(6): 945-58
24. Lazaridou E.,Giannopolou C,Fotiadou C et al The potencial role of microorganisms in the development of rosacea. J Dtsch Dermatol Ges 2011; 9(1): 1345 -9
25. Marks R, Harcourt-Webster JN. Histopathology of rosacea Arch Drmatol 1969; 100;686 92
26. Moriziane S,Yamasaki K, Kbigting FD, Gallo RL Kallikrein expression and cathelicidin processing are independly controlled in keratinocites by calcin,vitamin D3, and retinoic acid J Invest Dermatol 2010: 130: 1297 - 1307
27. Powell FC. Clinical practice. Rosacea N.Engl J Med 2005; 352; 793- 803
28. Del Rosso JQ, Gallo RL., Kircik et al Why is rosacea consirderd to be an inflammatory disorder ? The primary role, clinical relevance, and therapeutic correlations of abnormal innate immune response in rosacea - pron skin J Drugs Dermatol ,2012 Jun; 11(6) 694 -700
29. Culp B., Sheinfeld N. Rosacea : A revive. Pharm Ther 2009 2009: 34; 1; 38 -45
30. Chosidov O, Criber B. Epidemiology of rosacea ; updated data .Am Dermatol Venereol 2011,138 (suppl 2); s 124 - 8 [ in French}
31. Diamantis S,Waldorf HA . Rosacea: clinical presentation and pathophysiology. J Drugs Dermatol 2006; 5 (1); 8-12
32. Erbagci Z.,Ozgostavi O. The significance of Demodex folliculorum density in rosacea Int J Dermatol 1998; 37: 421 -5
33. Fotron F,Germaux MA,Rasseuer B, et al Demodecosis and rosacea: epidemiology and significance in daily dermatologie practice J Am Acad Dermatol 2005;52; 74 -87
34. Gutierrez EL,Galarza C.Ramos W et al Influence of climatic factors on the medical attencions of dermatologic disease in hospital of Lima,Peru.An Bras Drmatol 2010; 85)4); 461 -8
2. Ильин И.В., Санакоева Э.Г., Масюкова С.А. Современный взгляд на патогенез розацеа Эксп. и клин. дерматокосметология 2011; 1; 18 -20
3. Лоуэл А., Голдсмит Стивен И. и соат Дерматология Фицпатрика в клинической практике Изд. « Панфилова» Розацеа 2015 : 1019 -1028
4. Олисова О.Ю., Додина М.И. Роль фактора роста сосудистого эндотелия в патогенезе розацеа и его медикаментозная коррекция. Клин дерматол и венерол.2012; 1019 - 1028
5. Потекаев Н.Н Розацеа М. Бином 2000.
6. Потеаев Н.Н. Акне и розацеа : М.2007
7. Прохоренков В.И., Михель Д.В., Гузей Т.Н. Розацеа : современные аспекты этиологии и патогенеза Клин дерматол и венерол 2015; 1; 4-11
8. Самоделкина К.А.,Короткий Н.Г., Маяцкая Т.В. Современные концепции этиологии и патогенеза розацеа. Клин дерматол и венерол 2012; 3; 4-9
9. Хебиф Т.П Кожные болезни: диагностика и лечение Пер. с анг. под ред. акад. А. А Кубановой.
10. Abram K,Silm H., Maaroos HL., Oona M. Rsk factors associated with rosacea . J Eur Acad Dermatol Venereol 2010; 24: 565 -71
11. Aroni K.,Tsagroni E., Kavantas N. et al A study of the pathogenesis of rosacea . : how agiogenesis and mast cells may participate in a complex multifactorial process. Arch Dermatol Res 2008: 300: 125 -131
12. Wilkin JK. A role for vascular pathogenic mechanisms im rosacea : implications for patient care. Cutis 2008: 82 (2): 100-2
13. Webster GF. Rosacea. Med Clin North Am .2009 Nov (6) : 1183 -94
14. Shuber J,Gallo RL Antimicrobal peptides and the skin immune defense system. J Allergy Clin Immunol 2009: 124 (Suppl 2): 13-18
15. Smith JR, Lamier VB, Braziel RM. et al. Expression of vascular endothelial growth factor and its receptor in rosacea. Br J Oftalmol 2007: 91: 226 9
16. Slichcic A. The link between Helicobacter pylory infection and rosacea J Eur Acad Dermatol Venereol 2002 : 16: 328 -33
17. Shwab V. D.., Sulk M., Seeliger S et al. Neurovascular and neuroimmune aspects in the pathophysiology of rosacea J Invest Dermatol symp Proc 2011: 1: 53-62
18. Yamasaki K, Di Nardo A, Bardan A et al. Increased serine protease activity and catelicidin promotes skin inflammation in rosacea. Nat Med 2007; 13; 975 -80
19. Yamasaki K., Gallo RL., The molecular pathology of rosacea J Dermatol Sc. 2009 Aug; 55(2); 77-81
20. Jones DA., Rosacea, reactive oxygen species and azelaic acid. J Clin Aesthet Dermatol 2009 ; 2(1); 26 -30
21. Kyriakis K., Palamaras I, Terzoidi S et al. Epidemiologie aspects of rosacea. J Am Acad Dermatol 2005;53; 918 -9
22. Kligman A.M. A personal critigue on the state of rnowledge of Rosacea Dermatology Dermatology 2008;191 -198
23. Laguer V., Hoang V,Nguyen A et al. Angiogenesis in cutaneous disease; part II . J Am Acad Dermatol 2009; 61(6): 945-58
24. Lazaridou E.,Giannopolou C,Fotiadou C et al The potencial role of microorganisms in the development of rosacea. J Dtsch Dermatol Ges 2011; 9(1): 1345 -9
25. Marks R, Harcourt-Webster JN. Histopathology of rosacea Arch Drmatol 1969; 100;686 92
26. Moriziane S,Yamasaki K, Kbigting FD, Gallo RL Kallikrein expression and cathelicidin processing are independly controlled in keratinocites by calcin,vitamin D3, and retinoic acid J Invest Dermatol 2010: 130: 1297 - 1307
27. Powell FC. Clinical practice. Rosacea N.Engl J Med 2005; 352; 793- 803
28. Del Rosso JQ, Gallo RL., Kircik et al Why is rosacea consirderd to be an inflammatory disorder ? The primary role, clinical relevance, and therapeutic correlations of abnormal innate immune response in rosacea - pron skin J Drugs Dermatol ,2012 Jun; 11(6) 694 -700
29. Culp B., Sheinfeld N. Rosacea : A revive. Pharm Ther 2009 2009: 34; 1; 38 -45
30. Chosidov O, Criber B. Epidemiology of rosacea ; updated data .Am Dermatol Venereol 2011,138 (suppl 2); s 124 - 8 [ in French}
31. Diamantis S,Waldorf HA . Rosacea: clinical presentation and pathophysiology. J Drugs Dermatol 2006; 5 (1); 8-12
32. Erbagci Z.,Ozgostavi O. The significance of Demodex folliculorum density in rosacea Int J Dermatol 1998; 37: 421 -5
33. Fotron F,Germaux MA,Rasseuer B, et al Demodecosis and rosacea: epidemiology and significance in daily dermatologie practice J Am Acad Dermatol 2005;52; 74 -87
34. Gutierrez EL,Galarza C.Ramos W et al Influence of climatic factors on the medical attencions of dermatologic disease in hospital of Lima,Peru.An Bras Drmatol 2010; 85)4); 461 -8
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