ANTIMICROBIAL SCREENING OF COTINUS COGGYGGRIA SCOP LEAVES EXTRACT  FOR ITS APPLICATION IN ENDODONTICS

NATIA NIZHARADZE; TAMAR SHAVADZE; MARINE MAMALADZE; KETEVAN SHALASHVILI

doi:10.52340/jecm.2022.08.01

ANTIMICROBIAL SCREENING OF COTINUS COGGYGGRIA SCOP LEAVES EXTRACT FOR ITS APPLICATION IN ENDODONTICS

Авторы

NATIA NIZHARADZE Tbilisi State Medical University
TAMAR SHAVADZE Tbilisi State Medical University
MARINE MAMALADZE Tbilisi State Medical University
KETEVAN SHALASHVILI TSMU I. Kutateladze Institute of Pharmacochemistry

DOI:

https://doi.org/10.52340/jecm.2022.08.01

Ключевые слова:

Endodontic pathogens, Enterococcus faecalis, Cotinus coggygria Scop

Аннотация

For the new Millennium our knowledge of persistent bacteria, disinfecting agents and safety concerns has greatly increased and to achieve predictable, complete disinfection of the root canal system with minimal side-effects, there is no doubt that more innovative basic and biological approach is needed. In this sense, the search of alternative natural preparations for the disinfection of root canals remains relevant. The aim of our research was determination the antimicrobial activity of Cotinus coggygria leaves extract water solutions against Enterococcus faecalis. Microbiological study was conducted at the Laboratory of General Microbiology of Bacteriophage Analytical Diagnostic Center. The In vitro studies seems encouraging as 2% extract was found to be most effective against Streptococcus spp., while extract 10% solutions were observed to be most effective against Enterococcus faecalis. Pronounced antibacterial activity suggests successful application of Cotinus coggygria Scop extract solutions in Endodontic Practice. The in vivo study is in progress for recommending this novel herbal preparation as an alternative antimicrobial endodontic irrigating solution.

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ქემერტელიძე ეთერ, სხირტლაძე ალექსანდრე, შალაშვილი ქეთევან. თრიმლის Cotinus coggygria Scop. ფოთლებიდან გასუფთავებული ტანინის მიღების ხერხი. ინტელექტუალური საკუთრების ეროვნული სააგენტო- საქპატენტის ბიულეტენი, 2011, (45) # 15, სასარგებლო მოდელის პატენტი: (11) GE U 2011 1675 Y : (51) A 61 K 36/00 (IPC, 2006). გვ. (8)