A CASE OF FETAL GOITER: PRENATAL DIAGNOSIS, INTRAUTERINE TREATMENT  AND PREGNANCY FOLLOW UP

DAVID DAVARASHVILI; KETI SHALUTASHVILI; ANA DARGUASHVILI

doi:10.52340/jecm.2023.05.24

A CASE OF FETAL GOITER: PRENATAL DIAGNOSIS, INTRAUTERINE TREATMENT AND PREGNANCY FOLLOW UP

Authors

DAVID DAVARASHVILI David Davarashvili Clinic (DDC), Tbilisi, Georgia
KETI SHALUTASHVILI David Davarashvili Clinic (DDC), Tbilisi, Georgia
ANA DARGUASHVILI David Davarashvili Clinic (DDC), Tbilisi, Georgia

DOI:

https://doi.org/10.52340/jecm.2023.05.24

Abstract

Objective. Fetal goiter is found in about 1 in 5,000 births, usually in association with maternal Graves’s disease, due to trans placental passage of high levels of thyroid stimulating antibodies or of anti-thyroid drugs. The intrauterine recognition and treatment of congenital goitrous hypothyroidism may not only reduce the obstetric complications associated with large goiters, but possibly improve the prognosis for normal growth and mental development of affected fetuses

Methods. A 28-year-old Caucasian woman in her second ongoing pregnancy 21 weeks, was sent from another clinic to do genetic amniocentesis due to unexplained polyhydramnios. First pregnancy unexplained polyhydramnios, rupture of membrane, placenta abruption at 24 weeks, emergency C/S, death of fetus. Since the 9th week of pregnancy, prescribed by an endocrinologist she has been receiving Proturil (Propylthiuracil) due to thyrotoxicosis, in a daily dose of 150 mg. Since the 20th week, polyhydramnios has been diagnosed. An ultrasound examination in DDC revealed an enlarged fetal thyroid gland, bilobed symmetrical solid mass in the anterior aspect of the fetal neck with an approximate area of 1.36 cm2. The fetal head was extended and amniotic fluid index (AFI) was 35 cm. The fetal stomach appeared quite small. The fetal heart rate 172 bpm. No other abnormality was noted in the fetus and there were good fetal movements. The pregnant woman complained of shortness of breath, a feeling of heaviness in the pelvis.

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