CARDIOTOXICITY OF CYCLOPHOSPHAMIDE: CURRENT STATE OF THE PROBLEM
Keywords:cyclophosphamide, cardiotoxicity, immunosuppression
Cyclophosphamide is an alkylating anticancer drug, oxazaphosphorine-substituted nitrogen mustard, with pronounced cytotoxic and immunosuppressive potential. This drug is the basis of most immunosuppressive mode widely used for organ transplantation and chemotherapeutical treatment of the wide spectrum of malignant neoplasms of various localizations, particularly breast cancer, Hodgkin's disease, non-Hodgkin's lymphoma, leukemia, and others. Moreover, based on the V.A. Nasonova Institute of Rheumatology guidelines and the protocols of EULAR and ACR, cyclophosphamide is also used to treat inflammatory arthritis (rheumatoid-, lupus-, sclerodermic-, sarcoid- etc.), as well as for vasculitis. Moreover, cyclophosphamide-based pulse therapy is usually used in the cases of acute autoimmune processes with high activity index. Such a broad spectrum of cyclophosphamide prescription has become the explanation for the growing cases of cardiotoxicity consequence among cyclophosphamide-administered patients. This review article aims to assess and analyze the available data on the cyclophosphamide-driven disturbances of cardiovascular homeostasis.
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