OXIDATIVE STRESS, TYPE 2 DIABETES AND ASSESSMENT METHODS

SOPHO SAKHVADZE; MARINE NIKOLAISHVILI; RUSUDAN KVANCHAKHADZE; MAKA BULEISHVILI

doi:10.52340/jecm.2022.03.01

OXIDATIVE STRESS, TYPE 2 DIABETES AND ASSESSMENT METHODS

Authors

SOPHO SAKHVADZE David Agmashenebeli University of Georgia
MARINE NIKOLAISHVILI David Agmashenebeli University of Georgia
RUSUDAN KVANCHAKHADZE David Agmashenebeli University of Georgia
MAKA BULEISHVILI David Agmashenebeli University of Georgia

DOI:

https://doi.org/10.52340/jecm.2022.03.01

Keywords:

Oxidative stress, diabetes, norm, pathology, assessment methods

Abstract

The study of indicators of oxidative stress, which develops as a result of imbalances between oxidative and antioxidant systems, helps to identify the pathogenesis of many pathological processes, assess the risk of their occurrence and predict the characteristics. Elimination of oxidative stress helps to increase the effectiveness of prophylactic and therapeutic and rehabilitation measures.The above materials convince us of the need for extensive use of antioxidants in the complex therapy of ongoing acute and chronic diseases, in combination with other pathogenetic methods of treatment. The choice between them should be determined by the nature of the pathological process and the degree of its activity.

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References

Dos J. Santos, Moreli, M. L., Tewari, S. and Benite-Ribeiro, “The effect of exercise on skeletal muscle glucose uptake in type 2 diabetes: an epigenetic perspective,”Metabolism, vol. 64, no. 12, pp. 1619–1628, 2015.

Dos Santos, J. M. de Oliveira, D. S. Moreli, M. L and Benite-Ribeiro, S. A. “The role of mitochondrial DNA damage at skeletal muscle oxidative stress on the development of type 2 diabetes, ”Molecular and Cellular Biochemistry, vol. 449, no. 1-2, pp. 251 –255, 2018.

Miranda-Díaz, A. G. Pazarín-Villaseñor, L. Yanowsky-Escatell, F. G. and Andrade-Sierra, J. “Oxidative stress in diabetic nephropathy with early chronic kidney disease, ”Journal of Diabetes Research, vol. 2016, Article ID 7047238, 7 pages, 2016.

Ahmad, J. “Management of diabetic nephropathy: recent progress and future perspective,” Diabetes & Metabolic Syndrome: Clinical Research & Reviews, vol. 9, no. 4, pp. 343 –358, 2015.

Krause, M. Keane, K. Rodrigues-Krause J. et al., “Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause panreatic β-cell dysfunction and death in vitro,” Clinical Science, vol. 126, no. 10, pp. 739 –752, 2014.

Miao, X. Y. Gu, P. Liu Z. Y. et al., “The human glucagon-like peptide-1 analogue liraglutide regulates pancreatic beta-cell proliferation and apoptosis via an AMPK/mTOR/P70S6K signaling pathway,” Peptides, vol. 39, pp. 71–79, 2013

Ramachandran A., Levonen A.L., Brookes P.S. et al. Mitochondria, nitric oxide, and cardiovascular dysfunction. Free Radic Biol Med 2002; 33: 1465—1474.