DETECTION OF GASTRIC CANCER AT A LATE STAGE AS AN IMPORTANT FACTOR AFFECTING THE SURVIVAL OF PATIENTS

SABA  ZHIZHILASHVILI; IRAKLI  MCHEDLISHVILI; NANA  MEBONIA; ANNA  ZHIZHILASHVILI; MAIA  KERESELIDZE

doi:10.52340/jecm.2022.07.27

DETECTION OF GASTRIC CANCER AT A LATE STAGE AS AN IMPORTANT FACTOR AFFECTING THE SURVIVAL OF PATIENTS

Authors

SABA ZHIZHILASHVILI
IRAKLI MCHEDLISHVILI
NANA MEBONIA
ANNA ZHIZHILASHVILI
MAIA KERESELIDZE

DOI:

https://doi.org/10.52340/jecm.2022.07.27

Keywords:

gastric cancer, survival analysis, stage, mortality

Abstract

The study aims to assess the possible correlation between the gastric cancer (GC) stage at the detection and survival of patients in 2015-2020 in Georgia.

Methods. Bivariable survival Analysis using Cox’s regression model was constructed. A hazard (mortality) ratio (HR) was estimated by the stage at detection of GC. The level of statistical significance of the study findings is estimated by using the 95% of confidence interval (95%CI).

Results. Totally 2242 GC patients were enrolled in the study. Bivariate statistical analysis has revealed that the risk of early mortality from GC detected at the fourth (HR=4.8; 95%CI=3.3-6.8) and second (HR=1.9; 95%CI=1.3-2.7) or third (HR=2.2; 95%CI=1.5-3.2) stages is almost 5 and 2-times higher accordingly in comparison to cancer detected at the first stage.

Conclusions. A high proportion of GC cases are detected at the late stage in Georgia which is the main predictor of patients’ early mortality.

Downloads

Download data is not yet available.

References

ჟიჟლაშვილი ს, მჭედლიშვილი ი, მებონია ნ, ჟიჟლაშვილი ა. კუჭის კიბოს გავრცელების თავისებურებები საქართველოში, 2015-2020. ექსპერიმენტული და კლინიკური მედიცინა, 2021, (5-6): 47-50.

Huang RJ, Hwang JH. Improving the Early Diagnosis of Gastric Cancer. Gastrointest Endosc Clin N Am. 2021 Jul; 31(3):503-517.

Katanoda K, Ito Y, Sobue T. International comparison of trends in cancer mortality: Japan has fallen behind in screening-related cancers. Jpn J Clin Oncol. 2021 Nov 1; 51(11):1680-1686.

Qin Y, Tong X, Fan J, Liu Z, Zhao R, Zhang T, Suo C, Chen X, Zhao G. Global Burden and Trends in Incidence, Mortality, and Disability of Stomach Cancer From 1990 to 2017. Clin Transl Gastroenterol. 2021 Oct 5; 12(10): e00406.

Sekiguchi M, Oda I, Matsuda T, Saito Y. Epidemiological Trends and Future Perspectives of Gastric Cancer in Eastern Asia. Digestion. 2022; 103(1):22-28.

Wong MCS, Huang J, Chan PSF, Choi P, Lao XQ, Chan SM, Teoh A, Liang P. Global Incidence and Mortality of Gastric Cancer, 1980-2018. JAMA Netw Open. 2021 Jul 1; 4(7):e2118457.

Yang TW, Wang CC, Hung WC, Liu YH, Sung WW, Tsai MC. Improvement in the Mortality-to-Incidence Ratios for Gastric Cancer in Developed Countries with High Health Expenditures. Front Public Health. 2021 Aug 17; 9:713895.