FORMULATION AND TECHNOLOGY OF TARGETED DELIVERY AND MODIFIED-RELEASE SYSTEMS
While using conventional dosage forms, it is hard to avoid change (fluctuation, non-constancy) of the concentration of the active pharmaceutical ingredient (API) in biological fluids. At this time, it is possible to: overdose or conversely, have insufficient effectiveness of the drug; consumption of the medicinal substance in excess amount during use.
After delivering the API into the body, it is actually distributed evenly in all tissues. As a result, only an insignificant part of the active substance 0.001 - 0.01% is provided to the area of damage. The rest of the drug in the best case is wasted, or in the worst case, it causes a toxic effect .
Conventional dosage forms are not characterized by selectivity of release and action, so, the drug does not act like an arrow at a specific target, the action of the drug is like a rain. This is what determines the need for new approaches in the field of development of dosage forms
The study aimed to compose the formulations and develop technologies for targeted delivery and modified release dosage forms containing some natural and synthetic active pharmaceutical ingredients.