SYNTHESIS OF SOME DERIVATIVE QUINOXALINE

SYNTHESIS OF SOME DERIVATIVE QUINOXALINE

Authors

DOI:

https://doi.org/10.52340/gs.2023.05.01.21

Keywords:

quinoxaline hydrazone, diketones

Abstract

      In order to create medicinal preparations of some pharmacological action we deemed topical to develop an convenient preparative method for the synthesis of new isomeric qunoxalines. By condensation of 4-chlorophenylenediamine (1) with diphenylethanedione, 6-chloro-2,3-diphenylquinoxaline (2)  was synthesized. Quinolinhydrazine (3) was obtained by interaction of the mentioned chlorine products with hydrazine hydrate, and the corresponding 2,3-diphenyl-6-quinoxalinehydrazone was obtained by the action of ethylester of pyruvic acid on the latter. Composition and structure of synthesized compounds is determined by element analysis and physical methods of investigation.

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Author Biographies

Irma Jinikashvili, Tbilisi State Medical University

Ph.D. Assistant Professor of the Department of Medical Chemistry, Faculty of Pharmacy, Department of Medical Chemistry

Badri Arziani, Tbilisi State Medical University

Professor, head of the Department of Medical Chemistry, Faculty of Pharmacy, Department of Medical Chemistry.

References

S.P Singh., D.Kumar. Heterocycles 31 (1990), 31, 855.

S.P Singh., Savita., D.Kumar. Bull. Chem. Soc. Jpn. (1993), 66, 1703

A. Gil., A. Pabon., S.Galiano., A.Burguete., S.Perez-Silanes., E. Deharo., A. Monge and I.Aldana. Molecules 19 (2014), 2166-2180.

D.P. Singh., S.K. Deivedi, and R.G.Singhal. Pharmaceuticals (Basel). 2(2010) 8, 2416-2425.

J.Guillon., S. Moreau., M.Elisabeth and V. Sinou. Bioorganic & medicinal chemistry 16 (2008) 20, 9133-44.

R.Aggarwal., G.Sumran., R. Kumar, and S.P. Singh. General Papers Akivoc XV(2007), 292-302.

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Published

2023-03-21

How to Cite

Jinikashvili, I., & Arziani, B. (2023). SYNTHESIS OF SOME DERIVATIVE QUINOXALINE. GEORGIAN SCIENTISTS, 5(1), 249–252. https://doi.org/10.52340/gs.2023.05.01.21

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