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Even in the third year since the beginning of the pandemic, the negative consequences caused by COVID-19 pose a critical threat to the entire world. The aim of the study was to present most frequent manifestations of the post-COVID-19 syndrome. Health problems caused by COVID-19 continue beyond the acute phase of the disease. The manifestations are diverse and heterogeneous, but the most common among them are chronic fatigue syndrome and psychological distress. It is important to manage these manifestations in order to reduce the burden of the pandemics on the health care system.



Anaya JM, Rojas M, et al. Post-COVID study group, Monsalve DM, Acosta-Ampudia Y, Ramírez-Santana C. Post-COVID syndrome. A case series and comprehensive review.Autoimmun Rev. 2021 Nov;20(11):102947.

Banda JM, Singh GV, Alser O, Prieto-Alhambra D. Longterm patient-reported symptoms of COVID-19: an analysis of social media data. medRxiv. 2020.

Carfì A, Bernabei R, Landi F. Persistent Symptoms in Patients After Acute COVID19. JAMA 2020;324(6):603.

Cénat JM, Blais-Rochette C, et al. Prevalence of symptoms of depression, anxiety, insomnia, posttraumatic stress disorder, and psychological distress among populations affected by the COVID-19 pandemic: A systematic review and meta-analysis. Psychiatry Res. 2021 Jan;295:113599.

Cui, J., Li, F. & Shi, Z. L. Origin and evolution of pathogenic coronaviruses. Nat. Rev. Microbiol. 17, 181–192 (2019).

Deng J, Zhou F, Hou W, et al. The prevalence of depression, anxiety, and sleep disturbances in COVID-19 patients: a meta-analysis. Ann N Y Acad Sci. 2021 Feb;1486(1):90-111.

Deolmi M, Pisani F. Psychological and psychiatric impact of COVID-19 pandemic among children and adolescents. Acta Biomed. 2020 Nov 10;91(4):e2020149.

Fernández-de-Las-Peñas C, et al. Prevalence of post-COVID-19 symptoms in hospitalized and non-hospitalized COVID-19 survivors: A systematic review and meta-analysis. Eur J Intern Med. 2021 Oct;92:55-70.

Fernández-de-Las-Peñas C, Palacios-Ceña D, et al. Fatigue and Dyspnoea as Main Persistent Post-COVID-19 Symptoms in Previously Hospitalized Patients: Related Functional Limitations and Disability. Respiration. 2022;101(2):132-141.

Hickie I, Davenport T, Wakefield D, et al. Post-infective and chronic fatigue syndromes precipitated by viral and nonviral pathogens: prospective cohort study. Bmj.2006;333(7568):575.

Hossain MM, Tasnim S, et al. Epidemiology of mental health problems in COVID-19: a review. F1000Res. 2020 Jun 23;9:636.

Komaroff AL, Bateman L. Will COVID-19 Lead to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome? Front Med (Lausanne). 2021 Jan 18;7:606824.

Kotova OV, Medvedev VE, Poluektov MG, Belyaev AA, Akarachkova ES. Rasstroistva sna pri postkovidnom sindrome — problema psikhiatrii ili nevrologii? [Sleep disorders in post-COVID syndrome - a problem of psychiatry or neurology?]. Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122(5. Vyp. 2):23-28. Russian.

Lee SH, Shin H-S, et al. Depression as a Mediator of Chronic Fatigue and Post-Traumatic Stress Symptoms in Middle East Respiratory Syndrome Survivors. Psychiatry Investig 2019;16(1):59–64.

Mahmud R, Rahman MM, et al. PostCOVID-19 syndrome among symptomatic COVID-19 patients: A prospective cohort study in a tertiary care center of Bangladesh. PLoS One. 2021;16(4):e0249644.

Mandal S, Barnett J, Brill SE, et al. ‘Long-COVID’: a cross-sectional study of persisting symptoms, biomarker and imaging abnormalities following hospitalisation for COVID-19. Thorax 2020 [Online ahead of print].

Marone Diop I, Kokkinakis I, et al. Prise en charge des patients avec Covid long : illustration par des cas cliniques [Practical management of long Covid disease in outpatients: illustration by clinical cases]. Rev Med Suisse. 2021 Nov 10;17(758):1915-1921. French.

Mazza MG, Palladini M, Poletti S, Benedetti F. Post-COVID-19 Depressive Symptoms: Epidemiology, Pathophysiology, and pharmacological Treatment. CNS Drugs. 2022 Jul;36(7):681-702. doi: 10.1007/s40263-022-00931-3. Epub 2022 Jun 21.

Menachery V.D., Yount B.L., et al. A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence. Nat Med. 2015;21(12):1508–1513.

Moldofsky H, Patcai J. Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study. BMC Neurol 2011;11(1).

Munblit D, Nicholson T, et al. A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research: an international Delphi consensus study. Lancet Respir Med. 2022 Jul;10(7):715-724.

Nguyen NN, Hoang VT, et al. Clinical patterns of somatic symptoms in patients suffering from post-acute long COVID: a systematic review. Eur J Clin Microbiol Infect Dis.2022 Apr;41(4):515-545.

Perrin R, Riste L, Hann M, Walther A, Mukherjee A,Heald A. Into the looking glass: Post-viral syndrome post COVID-19. Med Hypotheses 2020;144:110055.

Raman B, Bluemke DA, Lüscher TF, Neubauer S. Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus. Eur Heart J. 2022 Mar 14;43(11):1157-1172.

Rosales-Castillo A, García de los Ríos C, Mediavilla García JD. Persistent symptoms after acute COVID-19 infection: importance of follow-up. Medicina Clínica (English Edition) 2021;156(1):35–6.

Salamanna F, Veronesi F, Martini L, et al. Post-COVID-19 Syndrome: The Persistent Symptoms at the Post-viral Stage of the Disease. A Systematic Review of the Current Data. Front Med (Lausanne). 2021;8:653516.

Soriano JB, Murthy S, Marshall JC, Relan P, Diaz JV; WHO Clinical Case Definition Working Group on Post-COV-ID-19 Condition. A clinical case definition of post-COVID-19 condition by a Delphi consensus. Lancet Infect Dis. 2022 Apr;22(4):e102-e107.

Townsend L, Dowds J, O’Brien K, et al. Persistent poor health after COVID-19 is not associated with respiratory complications or initial disease severity. Ann Am Thoracic Soc 2021;18(6):997–1003.

Vahedian-Azimi A, Moayed MS, et al. Comparison of the severity of psychological distress among four groups of an Iranian population regarding COVID-19 pandemic. BMC Psychiatry. 2020 Aug 8;20(1):402.

Valenzano A, Scarinci A, et al. The Social Brain and Emotional Contagion: COVID-19 Effects. Medicina (Kaunas). 2020 Nov 25;56(12):640.

Wang, L.; Byrum, B.; Zhang, Y. Detection and genetic characterization of deltacoronavirus in pigs, Ohio, USA, 2014. Emerg. Infect. Dis. 2014, 20, 1227–1230.

Wessely S: The History of Chronic Fatigue Syndrome. In Chronic Fatigue Syndrome Edited by: Strauss SE. New York: Marcel Dekker, Inc; 1994:3-4.

Wiech M, Chroscicki P, et al. Remodeling of T Cell Dynamics During Long COVID Is Dependent on Severity of SARS-CoV-2 Infection. Front Immunol. 2022 Jun 10;13:886431.

World Health Organization. International Health Regulations Emergency Committee on Novel Coronavirus in China. Available online: (accessed on 17 May 2020)

Wostyn P. COVID-19 and chronic fatigue syndrome:Is the worst yet to come? Med Hypotheses. 2021 Jan;146:110469.

Zhu, N.; Zhang, D. A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 2019.

Belouzard S, Millet JK, Licitra BN, Whittaker GR. Mechanisms of coronavirus cell entry mediated by the viral spike protein. Viruses. 2012 Jun;4(6):1011-33.

Backer JA, Klinkenberg D, Wallinga J. Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China, 20-28 January 2020. Euro Surveill. 2020 Feb;25(5):2000062.

Aly MAEG, Saber HG. Long COVID and chronic fatigue syndrome: A survey of elderly female survivors in Egypt. Int J Clin Pract. 2021 Dec;75(12):e14886.

Komaroff AL, Bateman L. Will COVID-19 Lead to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome? Front Med (Lausanne). 2021 Jan 18;7:606824.

Price JR, Mitchell E, Tidy E, Hunot V. Cognitive behaviour therapy for chronic fatigue syndrome in adults. Cochrane Database Syst Rev. 2008 Jul 16;2008(3):CD001027.

McLachlan KJJ, Gale CR. The effects of psychological distress and its interaction with socioeconomic position on risk of developing four chronic diseases. J Psychosom Res. 2018 Jun;109:79-85.


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