AbstractGianotti-Crosti syndrome or papular acrodermatitis is arare pathology that predominantly develops in children. Syn-drome is commonly associated with a viral infection, althoughvaccination sometimes acts as a trigger. We present a clini-cal case of a 4-year-old boy who was hospitalized in theclinic on the 6th day of a fever. Patient presented with fever,odynophagia, dysphagia, moderate dehydration, hepatosple-nomegaly, lymphadenopathy - enlarged submandibular andcervical lymph nodes and symmetrical rush (papules andvesicules) on face and extremities. Blood test showslymphocytosis, monocytosis, with an increased number ofatypical monocytes. An antibody study and PSR test con-firmed the Diagnosis of Ebstein Barr viral infection. Basedon rush type and spreading was diagnosed Gianotti-Crostisyndrome. A lot of studies confirmed the association of syn-drome with EBV infection. Symptomatic therapy was per-formed, which included rehydration, antihistamines, andemollients. After 1 week of hospitalization, patient was dis-charged from the clinic in an improved condition, althoughthe rash was not fully eliminated. Outpatient supervisionshows resolving of the rush at 4 weeks, lymphadenopathyat 6 weeks. The purpose of this case study was to considerdiagnosis of Gianotti-Crosti syndrome in case of a typicaltype and spreading of the rash in association with a viralinfection.
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