How to Cite

Pavliashvili , N., Gamkrelidze , N., Namoradze , M., Kvachadze , L., & Chelidze , N. (2023). PATHOGENESIS OF POLYORGANICDAMAGE CAUSED BY ALCOHOL. COLLECTION OF SCIENTIFIC WORKS OF TBILISI STATE MEDICAL UNIVERSITY, 55. Retrieved from


Alcohol is the most common recreational beverage in theworld, which is used for its mood altering properties, but itsexcessive consumption is associated with development ofmany types of physical and social harm, as its consumptioncauses the death of more than 100,000 people each year.Biotransformation of alcohol is carried out mainly in the liverby isoenzymes of three enzyme systems - alcohol dehydro-genase, cytochrome P-450 and catalase.Alcohol metabolism results in toxic effects: liver increas-es the synthesis of triglycerides and fatty liver develops.Alcohol also enhances free radical oxidation in liver and stim-ulates secretion of endotoxins by bacteria in the gut microf-lora.Alcohol consumption is the cause of vitally importantorgans and systems damage. These are: cardiovascular sys-tem, central nervous system, gastrointestinal tract, urogeni-tal, hepatobiliary systems.Correction of nutrition, vitamin deficiency, and controlof alcohol-related organ damage in alcohol-dependent sub-jects is advisable to prevent further complications


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