THE ROLE OF INFLAMMATORYCYTOKINES IN EPILEPSY
Epilepsy is one of the most common neurological disor-der affecting up to 1% of the world population. It is a heter-ogeneous disorder and includes genetic, structural, meta-bolic causes, sometimes the reason is unknown. In recent 20years, inflammation has been considered as a possible etio-logic factor in angiogenesis and epileptogenesis in experi-mental models but there is still a lack of evidence if inflamma-tion could be playing the role in clinical cases of childrenwith different forms of epilepsy. Epileptic encephalopathiesare the group of epilepsies when seizure itself can causesevere cognitive and behavioral abnormalities. Besides sei-zures occurring in epileptic encephalopathies are prone tobe highly resistant to medication. Thus any etiological fac-tor contributing to epileptogenesis could have high clinicalrelevance in modern epileptology. We review the latest sci-entific papers and publications that have demonstrated thepossible pathomechanismal role of inflammation in epilepto-genesis. The study of the role of inflammation as an impor-tant etiological factor in the generation and recurrence ofseizures, as well as considering the mechanism of resistance,especially in epileptic encephalopathies, may be the basisfor the development of new, selective add-on drugs anti-inflammatory medications, the use of which will be promis-ing in the treatment of refractory epilepsy.