Chylothorax and chyloperitoneum are unusual causes ofpleural and peritoneum effusions in neonates, that have vari-able incidence and a high rates of poor outcome. Recentlythe management of chylothorax is debatable and it is impor-tant to select an optimal treatment plan. Case: 36 weeks ges-tational aged male neonate, with birth weight 3.0 kg andApgar scores 7/7, developed severe respiratory distress af-ter birth. Based on radiological findings diaphragm herniawas diagnosed. After 14 days of surgery patient’s conditionworsened, due to severe respiratory distress, radiologic in-vestigation revealed presence of liquid in pleural cavity andperitoneum. Chest drainage was performed and a specimenof drainage was typical of lymph, with a high triglyceridelevel. Chylothorax and chyloperitoneum were diagnosed.Conservative therapy was started including full parenteralfeeding, without fat emulsions and high amino acids, de-compression of plural cavity by drainage and evacuation ofchylic fluid, mechanical ventilation. The condition of patientimproved minimally and infusion of Sandostatin was start-ed. After Sandostatin treatment patient’s condition improved,the amount of accumulated fluid in pleura and peritoneumdecreased, enteral feeding was started and after 12 days ofSandostatine treatment drainage was removed, at age of 1month and 25 days the patient was discharged from hospi-tal. So Sandostatin can be considered as an effective thera-py in cases when only drainage and parenteral feeding is notimproving patient’s condition.