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Gambashidze, K., SEPASHVILI, A., Pantsulaia, I., Bejitashvili, D., & Tediashvili, M. (2019). THE IMMUNE SYSTEM REACTION OF EHRLICH CARCINOMA BEARING MICE IN RESPONSE TO VACCINATIONS WITH THE USE OF PHAGELYSATE CONTAINING BACTERIAL PREPARATION. Collection of Scientific Works of Tbilisi State Medical University, 51, 100–103.


Anticancer treatment effects of E.coli phage lysate vaccinations (0,25 ml, 1x intraperitoneally, with 5 days interval) have been studied in 2-3 months old 30 lab. mice with Ehrlich carcinoma. The treatment efficacy was estimated by the dynamic of growth of cancer tissue and cancer growth inhibition percent. Immune system status was studied by measurement of IL-12 concentration with the use of ELISA. The trials have shown that E.coli phage lysate injections delay the cancer growth. Anticancer treatment effect was especially obvious and well expressed in case of 3 and 4 times vaccinations. During the same period increased secretion of IL- 12 in treated mice compared to the untreated and healthy control was detected. After 5-8 injections the anticancer action of the preparation decreased. Although the cancer volume in treated group animals was less than in the control’s one, the prolonged vaccinations supported further cancer growth. After 5-8 injections concentration of IL-12 was decreased as well. The peak of IL-12 secretion was reached on 3rd injection, but after 5-8 vaccinations there was no statistically significant difference between results of experimental and control group animals. Could be concluded that the bacterial preparation - E.coli phage lysate reveal anticancer immunomodulatory properties. For positive treatment results the detection of optimal dosage and regimen of vaccinations is important.


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