CALORIMETRIC STUDY OF THE STABILITY OF DPPS-LIPOSOMES AND С AND E VITAMINS COMPLEXES
Аннотация
The modem nanotechnology was used to encapsulate vitamins (С, E) in DPPC liposomes. Proportions of vitamins and DPPC lipids were selected as one vitamin per one lipid molecule. The hydrophobic vitamin E was located in hydrophobic part of liposome and the hydrophilic vitamin С - on the surface of a bilayer of liposomes’ membrane. The formation of such complex was confirmed with either calorimetric or biological experiments. In particular, calorimetric curve of the complex differs considerably from calorimetric peak profiles of the pure DPPC liposomes, that further emphasize the existence of vitamins and liposomes complex.
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Библиографические ссылки
Akbarzadeh A. et al. - Synthesis, characterization, and in vitro evaluation of novel polymer-coated magnetic nanoparticles for controlled delivery of doxorubicin// J. Nanotechnol. Sci. Appl., 2012, #5,13-25.
Al-Jamal Т., Kostarelos K. — Liposomc-nanoparticle hybrids for multimodal diagnostic and therapeutic applications// J. Nanomedicine. 2007. #2,85-98.
Agnieszka Z. et al. - Nanoparticles as drug deliver) systems// J. Pharmacological Reports. 2012. #64. 1020-1037.
Amamath S.. Sharma U. - Liposomes in drug delivery : progress and limitations// Int. J. Pharm.. 1997, #154 123-140.
Banerjee R. et al. - Anisamide-targeted stealth liposomes: a potent carrier for targeting doxorubicin to human prostate cancer cells// Int. J. Cancer. 2004, #112, 693-700.
Brown М.. Schatzlein A., Uchegbu I. - Gene delivery with synthetic (non viral) carriers// Inter. J. Pharmaceutics, 2001, #229, I-21.
Hofheinz R. et al. - Liposomal encapsulated anti-cancer drugs// Anticancer Drugs. 2005, #16.691-707.
Shaheen S. et al. - Liposome as a carrier for advanced drug delivery// Pak. J. Biol. Sci. 2006. #9(6) 1181-1191.
Riaz M. - Liposome preparation method// Pak. J. Pharm. Sci., 1996, #9(1), 65-77.
