EFFECTS OF GRAPEVINE SHOOTS EXTRACTS ON THE DEGREE OF OXIDATIVE STRESS IN LABORATORY RATS

EFFECTS OF GRAPEVINE SHOOTS EXTRACTS ON THE DEGREE OF OXIDATIVE STRESS IN LABORATORY RATS

Авторы

  • NATIA BOKUCHAVA Tbilisi State Medical University image/svg+xml
  • TAMAZ MURTAZASHVILI Tbilisi State Medical University image/svg+xml
  • NODAR MITAGVARIA Ivane Beritashvili Center of Experimental Biomedicine, Laboratory of Cerebral Blood Flow and Metabolism
  • KOBA SIVSIVADZE Tbilisi State Medical University image/svg+xml
  • MARIAM TATANASHVILI Tbilisi State Medical University image/svg+xml

DOI:

https://doi.org/10.52340/jecm.2023.04.34

Ключевые слова:

Polyphenols, Oxidative stress, FRAS-5, Vine shoots

Аннотация

Oxidative stress plays an important part in a number of disorders. ROS are extremely harmful compounds that are produced during metabolic reactions in the body and can interact with and damage cellular molecules including lipids, proteins, as well as other molecules. By-products from grape processing, such as shoots, canes, and pomace, are abundant in the wine industry. The interest to these goods is increasing because they can be exploited as a low-cost, widely available natural resource for the recovery of a wide range of bioactive compounds for pharmaceutical and cosmetic purposes rather than being wasted.

The aim of this study was to use waste product – grapevine shoots as a source of polyphenols and evaluate its impact on reduction of oxidative stress in laboratory rats. Extract from Saperavi grapevine shoots was given to experimental groups of rats during research instead of water. Heat stress was initiated by placing the rats in a heat chamber. At the end of experiment, blood samples were collected and the oxidative stress status was analyzed using d-ROMs and PAT tests on FRAS-5. Received results established substantial possibility of using Saperavi shoots extract for reduction of oxidative stress in laboratory rats. It is also noteworthy, that experimental group, which received preliminary treatment and afterwards was affected by heat stress, demonstrated better ability to fight against free radicals. Accordingly, derived from shoots extract, demonstrates strong ability to reduce oxidative stress and can be used as treating, as well as preventive agent.

Скачивания

Данные скачивания пока недоступны.

Библиографические ссылки

Mishra A., Sharma A.K, Kumar S, Saxena A.K, Pandey A. K. Bauhinia variegata leaf extracts exhibit considerable antibacterial, antioxidant, and anticancer activities; BioMed Research International. 2013; 2013:10.

Liu, Z.-Q. Bridging free radical chemistry with drug discovery: a promising way for finding novel drugs efficiently; Eur. J. Med. Chem. 2019; 189:112020. doi: 10.1016/j.ejmech.2019.112020

Tsao R. Chemistry and Biochemistry of Dietary Polyphenols; Nutrients. 2010; 2:1231-1246.

González-Centeno, M.R.; Comas-Serra, F.; Femenia, A.; Rosselló, C.; Simal, S. Effect of power ultrasound application on aqueous extraction of phenolic compounds and antioxidant capacity from grape pomace (Vitis vinifera L.); Experimental kinetics and modelling. Ultrason. Sonochem. 2014, 22:506-14.

Heim K.E., Tagliaferro A.R., Bobilya D.J. Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships; Journal of Nutritional Biochemistry. 2002; 13(10):572-584. doi: 10.1016/s0955-2863(02)00208-5.

C.A, Miller N.J, Paganga G. Free Radical, Rice-Evans, Biol. Med. 1996; 7:933.

Ilievska J, Cicimov V, Antova E, Gjorgoski I, Hadzy-Petrushev N, Mladenov M. Heat-induced oxidative stress and inflammation in rats in relation to age; 2016; 5(2):123-130. ISSN(Print):1857-8152; ISSN(Online):1857-8160

Reuter S., Gupta S.C, et al. Oxidative stress, inflammation, and cancer: how are they linked? Free Radic. Biol. Med. 2010; 49:1603-16. doi: 10.1016/j.freeradbiomed.2010.09.006

Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, Squadrito F, Altavilla D, Bitto A. Oxidative Stress: Harms and Benefits for Human Health; Oxidative Medicine and Cellular Longevity 2017, Article ID 8416763.

Zilich, O.V. et al. Polyphenols as active ingredients for cosmetic products; Int. J. Cosmet. Sci. 2015; 37: 455-464.

Kumar S., Sharma U.K., Sharma A.K, Pandey A.K. Protective efficacy of Solanum xanthocarpum root extracts against free radical damage: phytochemical analysis and antioxidant effect; Cellular and Molecular Biology. 2012;58(1):174-181. doi: 10.1170/t938.

Mishra A., Kumar S., Pandey A.K. Scientific validation of the medicinal efficacy of Tinospora cordifolia; The Scientific World Journal. 2013; 2013:8. doi: 10.1155/2013/292934.292934

Aminjan, H. H., Abtahi, S. R., Hazrati, E., Chamanara, M. et al. Targeting of oxidative stress and inflammation through ROS/NF-kappaB pathway in phosphine-induced hepatotoxicity mitigation; Life Sci. 2019; 232:116607.

Innovatics Laboratories, Inc. - https://innovaticslabs.com/fras5-2/

Innovatics Laboratories, Inc. - https://innovaticslabs.com/d-roms-fast-test/

Innovatics Laboratories, Inc. - https://innovaticslabs.com/pat-test/

H&D S.r.l - https://hedsrl.it/en/redox-ob-fast/#:~:text=REDOX%20OB%20

Загрузки

Опубликован

2023-11-27

Как цитировать

BOKUCHAVA, N., MURTAZASHVILI, T., MITAGVARIA, N., SIVSIVADZE, K., & TATANASHVILI, M. (2023). EFFECTS OF GRAPEVINE SHOOTS EXTRACTS ON THE DEGREE OF OXIDATIVE STRESS IN LABORATORY RATS. Experimental and Clinical Medicine Georgia, (4), 152–158. https://doi.org/10.52340/jecm.2023.04.34

Выпуск

Раздел

Articles

Наиболее читаемые статьи этого автора (авторов)

Похожие статьи

<< < 1 2 3 4 > >> 

Вы также можете начать расширеннвй поиск похожих статей для этой статьи.

Loading...