TY - JOUR AU - Katamadze Natia, AU - Kandashvili Tamar, AU - Metreveli David, AU - Gordeladze David, PY - 2021/07/23 Y2 - 2024/03/29 TI - THE ROLE OF GUT MICROBIOTA INPATIENTS WITH DIABETES TYPE 2AND INSULIN RESISTANCE JF - Collection of Scientific Works of Tbilisi State Medical University JA - CSW VL - 54 IS - SE - Articles DO - 10.52340/csw.2021.435 UR - https://journals.4science.ge/index.php/CSW/article/view/435 SP - 141-143 AB - <p>Diabetes mellitus is one of the most common chronic disease. In a number of developing and industrialized countries, diabetes mellitus has become an epidemic and is one of the leading causes of death. The rapid increase of cases of type 2 diabetes mellitus (T2DM) in the past decades has made it a widespread metabolic disorder. In recent years, an increasing understanding of how our microflora is linked to obesity-related T2DM has provided a new potential target for reducing the risk of T2DM.The aim of our project is to expand our view on the key roles of microflora during the onset and development of T2DM as well as its complications. Our aim wasto study 2 groups of people with T2DM and Prediabetes in order to reveal any gastro-intestinal problems. According to questionnaires, it  appeared  that  patients  with  diabetes  type  2  had  3  or  more  gastrointestinal  disorders,  72  %  had bloating,  16%  constipation  and  12%  diarrhea.  Patients  with  prediabetes  had  3  and  more  intestinal disorders: 56 % had bloating, 23% constipation and 21 % diarrhea. Despite, multiple studies supporting  the importance of gut microbiota  in pathophysiology of T2DM, the field is in early stage. Currently, we have reached a point in our understanding that some probiotics and related molecular mechanisms may be involved in glucose metabolism related to T2DM. We should work towards precision/personalized medicine selecting anti-diabeticsand probiotics for a given patient to treat patients successfully.</p> ER -