The role of type 2 diabetes in the pathogenesis of different cancers
To determine the possible causal relation between T2D and cancer has been the aim of our research, to study glycemic and insulin levels in patients with tumors of different localization. Methods: 202 patients were included in the study, 118 males and 84 females. Patients were divided into two groups: The first group - 107 patients who had diabetes and one of the cancers. Individuals in the second group were diagnosed with cancer without diabetes type 2. Glycemia and insulin levels were determined in patients in both groups. The mean glycemic index in the first group was 157 mg /dL (±18); 204 mg / dl (±22) 120 minutes after feeding. Insulin levels in first group were 34.3 micU / ml (±1.2); These data did not differ significantly between tumors of different localization. The study revealed the association of diabetes mellitus with tumor pathologies of various localizations. Reliable results were obtained between respiratory tumors (OR = 5.32), digestive tumors (OR = 9.35), female genital tumors (OR = 5.34), and the presence of diabetes. As for the association of urinary tract tumors with diabetes, the obtained results were not statistically reliable. There is a statistically reliable link between respiratory system, digestive system and female genital cancers and diabetes.
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